The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

HealthHORIZON-RIAID: 101057100
EC Contribution
€67,181
Consortium Size
22 orgs
Start Year
2022
Summary

The consequences of SARS-CoV-2 exposure range from a lack of infection to lethal COVID-19. This immense inter-individual clinical variability is the key scientific and medical enigma in the field. While age and certain co-morbidities are known to influence disease outcome, these parameters do not explain all variation. In addition, there are other SARS-CoV-2 phenotypes of clinical importance: multisystem inflammatory syndrome in children and adults (MIS-C/A), and longCOVID. An important breakthrough to unravel the pathogenesis of COVID-19 came from our two Science papers that were recognized by Nature among the top 10 discoveries of 2020. We found that about 4% of patients with critical COVID-19 pneumonia had inborn errors of immunity (IEI) that impair TLR3- and IRF7-dependent type I interferon (IFN) immunity and at least 10% of the patients carried pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs. These findings pave the way for further studies of COVID-19 pneumonia and other SARS-CoV-2 infection phenotypes and form the basis of the present research proposal, UNDINE, which follows a ""bed side to bench"" and ""bench to bed side"" approach, with the following objectivies i) to decipher the genetic and immunological basis of the various SARS-CoV-2 disease manifestations, to identify individuals at increased risk of critical COVID-19, post-infectious immunological complications, and vaccine failure iii) to develop ready-to-use diagnostic tests for large-scale detection of auto-Abs to type I IFNs and propose novel preventive and therapeutic approaches, based on the pathogenesis of SARS-CoV-2 infection for translation into personalised medicine. To achieve these goals, our project will coordinate a European multidisciplinary and translational research effort relying on a strong and synergistic combination of assets, including unique cohorts from 11 EU countries and state-of-the art human genetic, immunological and virological expertises and technologies.""

Consortium (22)

Project Results (86)

Source: CORDIS, the EU research results database.

Publications (73)
A Dynamic and Effective Peptide-Based Strategy for Promptly Addressing Emerging SARS-CoV-2 Variants of Concern
Pharmaceuticals· 2025DOI
Michela Murdocca, Isabella Romeo, Gennaro Citro, Andrea Latini, Federica Centofanti, Antonella Bugatti, Francesca Caccuri, Arnaldo Caruso, Francesco Ortuso, Stefano Alcaro, Federica Sangiuolo, Giuseppe Novelli
Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains
Journal of Experimental Medicine· 2025DOI
Fanny Saidoune, Danyel Lee, Jeremy Di Domizio, Corentin Le Floc’h, Raphael Jenelten, Jérémie Le Pen, Vincent Bondet, Ana Joncic, Marie-Anne Morren, Vivien Béziat, Shen-Ying Zhang, Emmanuelle Jouanguy, Darragh Duffy, Charles M. Rice, Curdin Conrad, Jacques Fellay, Jean-Laurent Casanova, Michel Gilliet, Ahmad Yatim
Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2
Human Genomics· 2025DOI
Patrizia Malaspina, Carla Jodice, Bianca Maria Ciminelli, Michela Biancolella, Vito Luigi Colona, Andrea Latini, Francesca Leonardis, Paola Rogliani, Antonio Novelli, Giuseppe Novelli, Andrea Novelletto
Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID
Journal of Medical Virology· 2025DOI
Kristoffer Skaalum Hansen, Sofie Eg Jørgensen, Cagla Cömert, Berit Schiøttz‐Christensen, Peter Bross, Jane Agergaard, Steffen Leth, Lars Østergaard, Johan Palmfeldt, Rikke Katrine Jentoft Olsen, Trine H. Mogensen
Host cell entry and neutralisation sensitivity of the emerging SARS-CoV-2 variant LP.8.1
The Lancet Infectious Diseases· 2025DOI
Lu Zhang, Amy Kempf, Inga Nehlmeier, Nianzhen Chen, Metodi V Stankov, Christine Happle, Alexandra Dopfer-Jablonka, Georg M N Behrens, Markus Hoffmann, Stefan Pöhlmann
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D
Journal of Virology· 2025DOI
Prerna Arora, Lu Zhang, Inga Nehlmeier, Amy Kempf, Luise Graichen, Eike Kreitz, Anzhalika Sidarovich, Cheila Rocha, Sabine Gärtner, Michael Winkler, Sebastian Schulz, Hans-Martin Jäck, Markus Hoffmann, Stefan Pöhlmann
Humoral immunity after mRNA SARS-CoV-2 omicron JN.1 vaccination
The Lancet Infectious Diseases· 2025DOI
Christine Happle, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Metodi V Stankov, Noemi Calderon Hampel, Torsten Witte, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Immune responses following BNT162b2 XBB.1.5 vaccination in patients on haemodialysis in Germany
The Lancet Infectious Diseases· 2025DOI
Anne Cossmann, Markus Hoffmann, Metodi V Stankov, Karsten Lürken, Gema Morillas Ramos, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Human Genetics and Genomics Advances· 2025DOI
Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Jean-Laurent Casanova, Giorgio Casari, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein Husebye, Kohsuke Imai, Yuval Itan, Emmanuelle Jouanguy, Elżbieta Kaja, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davood Mansouri, László Maródi, France Mentré, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine H. Mogensen, Tomohiro Morio, Lisa F.P. Ng, Luigi D. Notarangelo, Antonio Novelli, Giuseppe Novelli, Cliona O'Farrelly, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Jean W. Pape, Rebeca Perez de Diego, Jordi Perez-Tur, David S. Perlin, Graziano Pesole, Anna M. Planas, Carolina Prando, Aurora Pujol, Anne Puel, Lluis Quintana-Murci, Sathishkumar Ramaswamy, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Anna Sediva, Mikko R.J. Seppänen, Mohammad Shahrooei, Anna Shcherbina, Ondrej Slaby, Andrew L. Snow, Pere Soler-Palacín, Vassili Soumelis, András N. Spaan, Ivan Tancevski, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Pierre Tiberghien, Sophie Trouillet-Assant, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Donald C. Vinh, Horst von Bernuth, Joost Wauters, Mayana Zatz, Pawel Zawadzki, Qian Zhang, Shen-Ying Zhang, Serge Bureau, Yannick Vacher, Anne Gysembergh-Houal, Lauren Demerville, Abla Benleulmi-Chaachoua, Sebastien Abad, Radhiya Abassi, Abdelrafie Abdellaoui, Abdelkrim Abdelmalek, Hendy Abdoul, Helene Abergel, Fariza Abeud, Sophie Abgrall, Noemie Abisror, Marylise Adechian, Nordine Aderdour, Hakeem Farid Admane, Frederic Adnet, Sara Afritt, Helene Agostini, Claire Aguilar, Sophie Agut, Tommaso Francesco Aiello, Marc Ait Kaci, Hafid Ait Oufella, Gokula Ajeenthiravasan, Virginie Alauzy, Fanny Alby-Laurent, Lucie Allard, Marie-Alexandra Alyanakian, Blanca Amador Borrero, Sabrina Amam, Lucile Amrouche, Marc Andronikof, Dany Anglicheau, Nadia Anguel, Djillali Annane, Mohammed Aounzou, Caroline Aparicio, Gladys Aratus, Jean-Benoit Arlet, Jeremy Arzoine, Elisabeth Aslangul, Mona Assefi, Adeline Aubry, Laetitia Audiffred, Etienne Audureau, Christelle Nathalie Auger, Jean-Charles Auregan, Celine Awotar, Sonia Ayllon Milla, Delphine Azan, Laurene Azemar, Billal Azzouguen, Marwa Bachir Elrufaai, Aïda Badsi, Prissile Bakouboula, Coline Balcerowiak, Fanta Balde, Elodie Baldivia, Eliane-Flore Bangamingo, Amandine Baptiste, Fanny Baran-Marszak, Caroline Barau, Nathalie Barget, Flore Baronnet, Romain Barthelemy, Jean-Luc Baudel, Camille Baudry, Elodie Baudry, Laurent Beaugerie, Adel Belamri, Nicolas Belaube, Rhida Belilita, Pierre Bellassen, Rawan Belmokhtar, Isabel Beltran, Ruben Benainous, Mourad Benallaoua, Robert Benamouzig, Amélie Benbara, Jaouad Benhida, Anis Benkhelouf, Jihene Benlagha, Chahinez Benmostafa, Skander Benothmane, Miassa Bentifraouine, Laurence Berard, Que
Preclinical development of humanized monoclonal antibodies against CD169 as a broad antiviral therapeutic strategy
Biomedicine & Pharmacotherapy· 2025DOI
Patricia Resa-Infante, Itziar Erkizia, Xabier Muñiz-Trabudua, Federica Linty, Arthur E.H. Bentlage, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Dàlia Raïch-Regué, Nuria Izquierdo-Useros, Theo Rispens, Gestur Vidarsson, Javier Martinez-Picado
Rapid Detection of Anti‐IFN‐α2 Autoantibodies Using a New Automated VIDAS Assay Prototype
European Journal of Immunology· 2025DOI
Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel‐Pesce, Kahina Saker, Jean‐Christophe Richard, Alexis Mathian, Zahir Amoura, Karim Dorgham, Guy Gorochov, Jean‐Laurent Casanova, Aurore Fleurie, Sophie Trouillet‐Assant
SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency
Cell· 2025DOI
Lu Zhang, Amy Kempf, Inga Nehlmeier, Anne Cossmann, Anja Richter, Najat Bdeir, Luise Graichen, Anna-Sophie Moldenhauer, Alexandra Dopfer-Jablonka, Metodi V. Stankov, Etienne Simon-Loriere, Sebastian R. Schulz, Hans-Martin Jäck, Luka Čičin-Šain, Georg M.N. Behrens, Christian Drosten, Markus Hoffmann, Stefan Pöhlmann
Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies
The Journal of Infectious Diseases· 2025DOI
Federica Barzaghi, Camilla Visconti, Giovanni Battista Pipitone, Simone Bondesan, Giulia Molli, Stefania Giannelli, Claudia Sartirana, Vito Lampasona, Elena Bazzigaluppi, Cristina Brigatti, Adrian Gervais, Paul Bastard, Chiara Tassan Din, Chiara Molinari, Lorenzo Piemonti, Jean-Laurent Casanova, Paola Carrera, Giorgio Casari, Alessandro Aiuti
A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity
Journal of Experimental Medicine· 2024DOI
Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada-Velez, Marie Materna, Daniel C. Lin, Baptiste Milisavljevic, Fernanda Vianna, Lucy Bizien, Lazaro Lorenzo, Marc Lecuit, Jean-David Pommier, Sevgi Keles, Tayfun Ozcelik, Sigifredo Pedraza-Sanchez, Nicolas de Prost, Loubna El Zein, Hassan Hammoud, Lisa F.P. Ng, Rabih Halwani, Narjes Saheb Sharif-Askari, Yu Lung Lau, Anthony R. Tam, Neha Singh, Sagar Bhattad, Yackov Berkun, Wasun Chantratita, Raúl Aguilar-López, Mohammad Shahrooei, null null, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Ana Bertha Alcántara-Garduño, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Paul Bastard, Alexandre Bolze, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Sotiriјa Duvlis, Xavier Duval, Munis Dündar, Soha Fakhreddine, Jacques Fellay, Carlos Flores, José Luis Franco, Guy Gorochov, Peter K. Gregersen, David Hagin, Rabih Halwani, María Teresa Herrera, Ivan Fan-Ngai Hung, Emmanuelle Jouanguy, Yu-Lung Lau, Daniel Leung, Tom Le-voyer, Davood Mansouri, Jesús Mercado-García, Isabelle Meyts, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Satoshi Okada, Firat Ozcelik, Tayfun Ozcelik, Rebeca Perez de Diego, Jordi Perez-Tur, Graziano Pesole, Anne Puel, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Manal Sbeity, Sahar Sedighzadeh, Mohammad Shahrooei, Pere Soler-Palacín, András N. Spaan, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Ibrahim Torktaz, Sophie Trouillet-Assant, Stuart E. Turvey, Furkan Uddin, Fernanda Sales Luiz Vianna, Donald C. Vinh, Oscar Zabaleta-Martínez, Qian Zhang, Shen-Ying Zhang, Jean-Laurent Casanova, null null, Chanreaksmey Eng, Kimrong Bun, MengHeng Oum, Patrice Piola, Arnaud Tarantola, Mey Channa, Veasna Duong, Philippe Buchy, Chris Gorman, Jean-David Pommier, Yoann Crabol, Philippe Dussart, M. Bunleat, M. Panha, M.Kanarith Sim, Em Bunnakea, Denis Laurent, Heng Sothy, Ky Santy, Anousone Douangnouvong, Danoy Chommanam, Khansoudaphone Phakhounthong, Manivanh Vongsouvath, Malee Seephone, Bountoy Sibounheunang, Sayaphet Rattanavong, Viengmon Davong, Malavanh Vongsouvath, Mayfong Mayxay, Audrey Dubot-Pérès, Paul N. Newton, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Dang Duc Anh, Do Quyen, Tran Thi Mai Hung, Nguyen Thi Thu Thuy, Luong Minh Tan, Anh Tuan Pham, Nguyen Hien, Do Thu Huong, Le Thanh Hai, Nguyen Van Lam, Pham Nhat An, Phan Huu Phuc, Phung Bich Thuy, Tran Thi Thu Huong, Chaw Su Hlaing, Aye Mya Min Aye, Cho Thair, Kyaw Linn, May July, Win Thein, Latt Latt Kyaw, Htay Htay Tin, Ommar Swe Tin, Khin Yi Oo, Yoann Crabol, Magali Herrant, Magali Lago, Maud Seguy, Marc Jouan, Lukas Hafner, Philippe Pérot, Marc Eloit, Marc Lecuit, Olivier Lortholary, Julien Capelle, Bruno Rosset, Veronique Chevalier, Jérôme Honnorat, Anne Laurie Pinto, Auey Dubot-Peres, Xavier de Lamballerie, Kevin Bleakley, Bernadette Murgue, Catherine Ferrant, Christian Devaux, Hervé Tissot-Dupont, Jean-Paul Moatti, Mayfong Mayxay, Pascal Bonnet, Didier Fontenille, Jean-François Delfraissy, Patrice Debré, Benoit Durand, Laurent Abel, Paul Bastard, Emmanuelle Jouanguy, Vivien Béziat, Peng Zhang, Charles M. Rice, Aurélie Cobat, Shen-Ying Zhang, Paul J. Hertzog, Jean-Laurent Casanova, Qian Zhang
A sensitive assay for measuring whole-blood responses to type I IFNs
Proceedings of the National Academy of Sciences· 2024DOI
Adrian Gervais, Corentin Le Floc’h, Tom Le Voyer, Lucy Bizien, Jonathan Bohlen, Fatih Celmeli, Fahd Al Qureshah, Cécile Masson, Jérémie Rosain, Marwa Chbihi, Romain Lévy, Riccardo Castagnoli, Anya Rothenbuhler, Emmanuelle Jouanguy, Qian Zhang, Shen-Ying Zhang, Vivien Béziat, Jacinta Bustamante, Anne Puel, Paul Bastard, Jean-Laurent Casanova
Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease
Journal of Experimental Medicine· 2024DOI
Adrian Gervais, Paul Bastard, Lucy Bizien, Céline Delifer, Pierre Tiberghien, Chaturaka Rodrigo, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Francesca Conti, Irene Cassaniti, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Davide Mileto, Alessandro Mancon, Laurent Abel, Anne Puel, Aurélie Cobat, Charles M. Rice, Dániel Cadar, Jonas Schmidt-Chanasit, Johannes F. Scheid, Jacob E. Lemieux, Eric S. Rosenberg, Marianna Agudelo, Stuart G. Tangye, Alessandro Borghesi, Guillaume André Durand, Emilie Duburcq-Gury, Braulio M. Valencia, Andrew R. Lloyd, Anna Nagy, Margaret M. MacDonald, Yannick Simonin, Shen-Ying Zhang, Jean-Laurent Casanova
Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19
Biology Direct· 2024DOI
Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti, Federica Sangiuolo, Jean Jacques Vanden Eynde, Giuseppe Novelli
Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants
European Journal of Immunology· 2024DOI
Matthias Bruhn, Maureen Obara, Abdus Salam, Bibiana Costa, Annett Ziegler, Inken Waltl, Andreas Pavlou, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Axel Schambach, Ulrich Kalinke
Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk
Genes & Immunity· 2024DOI
Maxime Rotival, Lluis Quintana-Murci
Health Care Personnel Workdays Lost and Direct Health Care Salary Costs Incurred due to COVID-19 Infection in the Age of Widespread Vaccine Availability
The Journal of Infectious Diseases· 2024DOI
Liam Townsend, Paddy Gillespie, Jonathan McGrath, Claire Kenny, null null, Lorraine Doherty, Lisa Domegan, Niall Conlon, Greg Martin, Cillian de Gascun, Joan Gallagher, Mary Keogan, Noirin Noonan, Cliona O’Farrelly, David Byrne, Colm Bergin, Catherine Fleming
Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)
Journal of Experimental Medicine· 2024DOI
Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, null null, Alessandro Aiuti, Laia Alsina, Evangelos Andreakos, Ana de Andrés Martín, Catherine M. Biggs, Alessandro Borghesi, Amed Aziz Bousfiha, Daniel Blazquez-Gamero, Petter Brodin, Giorgio Casari, Antonio Condino-Neto, Jacques Fellay, Carlos Flores, Guy Gorochov, Emine Hafize Erdeniz, Lennart Hammarström, Yolanda Jordan Garcia, Adem Karbuz, Adam Klocperk, Paloma Lapuente-Suanzes, Yu-Lung Lau, Cheng Leung, Davood Mansouri, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Keisuke Okamoto, Satoshi Okada, Qiang Pan-Hammarström, Graziano Pesole, Laurent Renia, Carlos Rodriguez-Gallego, Anna Sediva, Mohammad Shahrooei, Pere Soler-Palacin, András N. Spaan, Gonul Tanir, Ahmad Abou Tayoun, Şehime G. Temel, Donald C. Vinh, null null, Aubrey Cunnington, Jethro Herberg, Myrsini Kaforou, Victoria J. Wright, Evangelos Bellos, Claire Broderick, Samuel Channon-Wells, Samantha Cooray, Tisham De, Giselle D'Souza, Leire Estramia Elorrieta, Diego Estrada-Rivadeneyra, Rachel Galassini, Dominic Habgood-Coote, Shea Hamilton, Heather Jackson, James Kavangh, Ila Keren, Mahdi Moradi Marjaneh, Stephanie Menikou, Samuel Nichols, Ruud Nijman, Ivana Pennisi, Oliver Powell, Ruth Reid, Priyen Shah, Ortensia Vito, Elizabeth Whittaker, Clare Wilson, Rebecca Womersley, Ami Abdulla, Sarah Darnell, Sobia Mustafa, Pantelis Georgiou, Jesus-Rodriguez Manzano, Nicolas Moser, Michael Carter, Shane Tibby, Jonathan Cohen, Francesca Davis, Julia Kenny, Paul Wellman, Marie White, Matthew Fish, Aislinn Jennings, Manu Shankar-Hari, Katy Fidler, Dan Agranoff, Vivien Richmond, Mathhew Seal, Saul Faust, Dan Owen, Ruth Ensom, Sarah McKay, Mariya Shaji, Rachel Schranz, Prita Rughni, Amutha Anpanthar, Susan Liebeschuetz, Anna Riddell, Divya Divakaran, Louise Han, Nosheen Khalid, Ivone Lancoma Malcolm, Jessica Schofield, Teresa Simagan, Mark Peters, Alasdair Bamford, Lauran O'Neill, Nazima Pathan, Esther Daubney, Deborah White, Melissa Heightman, Sarah Eisen, Terry Segal, Lucy Wellings, Simon B. Drysdale, Nicole Branch, Lisa Hamzah, Heather Jarman, Maggie Nyirenda, Lisa Capozzi, Emma Gardiner, Robert Moots, Magda Nasher, Anita Hanson, Michelle Linforth, Sean O'Riordan, Don Ellis, Akash Deep, Ivan Caro, Fiona Shackley, Arianna Bellini, Stuart Gormley, Samira Neshat, Barnaby Scholefield, Ceri Robbins, Helen Winmill, Stéphane C. Paulus, Andrew J. Pollard, Mark Anthony, Sarah Hopton, Danielle Miller, Zoe Oliver, Sally Beer, Bryony Ward, Shrija Shrestha, Meeru Gurung, Puja Amatya, Bhishma Pokhrel, Sanjeev Man Bijukchhe, Madhav Chandra Gautam, Sarah Kelly, Peter O'Reilly, Sonu Shrestha, Federico Martinón-Torres, Antonio Salas, Fernando Álvez González, Sonia Ares Gómez, Xabier Bello, Mirian B
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Journal of Experimental Medicine· 2024DOI
Paul Bastard, Adrian Gervais, Maki Taniguchi, Liisa Saare, Karita Särekannu, Tom Le Voyer, Quentin Philippot, Jérémie Rosain, Lucy Bizien, Takaki Asano, Marina Garcia-Prat, Alba Parra-Martínez, Mélanie Migaud, Miyuki Tsumura, Francesca Conti, Alexandre Belot, Jacques G. Rivière, Tomohiro Morio, Junko Tanaka, Etienne Javouhey, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Yacine Tandjaoui-Lambiotte, Simon Escoda, Maya Husain, Qiang Pan-Hammarström, Lennart Hammarström, Gloria Ahlijah, Anthony Abi Haidar, Camille Soudee, Vincent Arseguel, Hassan Abolhassani, Sabina Sahanic, Ivan Tancevski, Yoko Nukui, Seiichi Hayakawa, George P. Chrousos, Athanasios Michos, Elizabeth-Barbara Tatsi, Filippos Filippatos, Agusti Rodriguez-Palmero, Jesus Troya, Imran Tipu, Isabelle Meyts, Lucie Roussel, Sisse Rye Ostrowski, Laire Schidlowski, Carolina Prando, Antonio Condino-Neto, Nathalie Cheikh, Ahmed A. Bousfiha, Jalila El Bakkouri, null null, Sergio Aguilera-Albesa, Suzan A. AlKhater, Gulsum Alkan, Riccardo Castagnoli, Cyril Cyrus, Sefika Elmas Bozdemir, Melike Emiroglu, Belgin Gulhan, Emine Hafize Erdeniz, Nevin Hatipoglu, Gülsün Iclal Bayhan, Petr Jabandziev, Saliha Kanik Yuksek, Adem Karbuz, Şadiye Kübra Tüter Öz, Gian Luigi Marseglia, Ozge Metin Akcan, Ahmet Osman Kılıç, Aslinur Ozkaya Parlakay, Maria Papadaki, Katerina Slaba, Esra Sevketoglu, Juan Valencia-Ramos, Aysun Yahşi, null null, Antonio Aguilera Guirao, Julián Álvarez Escudero, Antonio Antela López, Gema Barbeito Castiñeiras, Xabier Bello Paderne, Miriam Ben García, María Victoria Carral García, Miriam Cebey López, Amparo Coira Nieto, Mónica Conde Pájaro, José Javier Costa Alcalde, María José Currás Tuala, Ana Isabel Dacosta Urbieta, Blanca Díaz Esteban, María Jesús Domínguez Santalla, Cristina Fernández Pérez, Juan Fernández Villaverde, Cristóbal Galbán Rodríguez, José Luis García Allut, Luisa García Vicente, Elena Giráldez Vázquez, Alberto Gómez Carballa, José Gómez Rial, Francisco Javier González Barcala, Beatriz Guerra Liñares, Pilar Leboráns Iglesias, Beatriz Lence Massa, Marta Lendoiro Fuentes, Montserrat López Franco, Ana López Lago, Federico Martinón-Torres, Antonio Salas, Daniel Navarro De la Cruz, Eloína Núñez Masid, Juan Bautista Ortolá Devesa, Jacobo Pardo Seco, María Pazo Núñez, Marisa Pérez del Molino Bernal, Hugo Pérez Freixo, Lidia Piñeiro Rodríguez, Sara Pischedda, Manuel Portela Romero, Antonio Pose Reino, Gloria María Prada Hervella, Teresa Queiro Verdes, Lorenzo Redondo Collazo, Patricia Regueiro Casuso, Susana Rey García, Sara Rey Vázquez, Vanessa Riveiro Blanco, Irene Rivero Calle, Carmen Rivero Velasco, Nuria Rodríguez Núñez, Carmen Rodríguez-Tenreiro Sánchez, Eva Saborido Paz, José Miguel Sadiki Orayyou, Carla Saito Villanueva, Sonia Serén Fernández, Pablo Souto Sanmartín, Manuel Taboada Muñiz, Rocío Trastoy Pena, Mercedes Treviño Castellano, Luis Valdés Cuadrado, Pablo Varela García, María Soledad Vilas Iglesias, Sandra Viz Lasheras, Rocio Ferreiro-Iglesias, Iria Bastón-Rey, Cristina Calviño-Suárez, null null, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Jean-Laurent Casanova, Giorgio Casari, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023
Immunological Reviews· 2024DOI
Paul Bastard, Adrian Gervais, Tom Le Voyer, Quentin Philippot, Aurélie Cobat, Jérémie Rosain, Emmanuelle Jouanguy, Laurent Abel, Shen‐Ying Zhang, Qian Zhang, Anne Puel, Jean‐Laurent Casanova
Human determinants of age-dependent patterns of death from infection
Immunity· 2024DOI
Laurent Abel, Jean-Laurent Casanova
Human life within a narrow range: The lethal ups and downs of type I interferons
Science Immunology· 2024DOI
Yanick J. Crow, Jean-Laurent Casanova
Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination
The Lancet Infectious Diseases· 2024DOI
Metodi V Stankov, Markus Hoffmann, Rodrigo Gutierrez Jauregui, Anne Cossmann, Gema Morillas Ramos, Theresa Graalmann, Emily Jo Winter, Michaela Friedrichsen, Inga Ravens, Tamara Ilievska, Jasmin Ristenpart, Anja Schimrock, Stefanie Willenzon, Gerrit Ahrenstorf, Torsten Witte, Reinhold Förster, Amy Kempf, Stefan Pöhlmann, Swantje I Hammerschmidt, Alexandra Dopfer-Jablonka, Georg M N Behrens
IL-7–dependent and –independent lineages of IL-7R–dependent human T cells
Journal of Clinical Investigation· 2024DOI
Carlos A. Arango-Franco, Masato Ogishi, Susanne Unger, Ottavia M. Delmonte, Julio César Orrego, Ahmad Yatim, Margarita M. Velasquez-Lopera, Andrés F. Zea-Vera, Jonathan Bohlen, Marwa Chbihi, Antoine Fayand, Juan Pablo Sánchez, Julian Rojas, Yoann Seeleuthner, Tom Le Voyer, Quentin Philippot, Kathryn J. Payne, Adrian Gervais, Lucia V. Erazo-Borrás, Luis A. Correa-Londoño, Axel Cederholm, Alejandro Gallón-Duque, Pedro Goncalves, Jean-Marc Doisne, Liran Horev, Bénédicte Charmeteau-de Muylder, Jesús Á. Álvarez, Diana M. Arboleda, Lizet Pérez-Zapata, Estefanía Vásquez-Echeverri, Marcela Moncada-Vélez, Juan A. López, Yolanda Caicedo, Boaz Palterer, Pablo J. Patiño, Carlos J. Montoya, Matthieu Chaldebas, Peng Zhang, Tina Nguyen, Cindy S. Ma, Mohamed Jeljeli, Juan F. Alzate, Felipe Cabarcas, Taushif Khan, Darawan Rinchai, Jean-Luc Prétet, Bertrand Boisson, Nico Marr, Ruba Ibrahim, Vered Molho-Pessach, Stéphanie Boisson-Dupuis, Dimitra Kiritsi, João T. Barata, Nils Landegren, Bénédicte Neven, Laurent Abel, Andrea Lisco, Vivien Béziat, Emmanuelle Jouanguy, Jacinta Bustamante, James P. Di Santo, Stuart G. Tangye, Luigi D. Notarangelo, Rémi Cheynier, Ken Natsuga, Andrés A. Arias, José Luis Franco, Klaus Warnatz, Jean-Laurent Casanova, Anne Puel
Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants
Clinical Immunology· 2024DOI
Liam Townsend, Jean Dunne, Jacklyn Sui, Carla Sanchez Perez, Matt McElheron, Cian Reid, William McCormack, Colm Bergin, Catherine Fleming, Cliona O'Farrelly, Gareth Brady, Niall Conlon
Impact of socioeconomic status on healthy immune responses in humans
Immunology & Cell Biology· 2024DOI
Anthony Bertrand, Jamie Sugrue, Tianai Lou, Nollaig M Bourke, Lluis Quintana‐Murci, Violaine Saint‐André, Cliona O'Farrelly, Darragh Duffy, null null
Inherited human RelB deficiency impairs innate and adaptive immunity to infection
Proceedings of the National Academy of Sciences· 2024DOI
Tom Le Voyer, Majistor Raj Luxman Maglorius Renkilaraj, Kunihiko Moriya, Malena Pérez Lorenzo, Tina Nguyen, Liwei Gao, Tamar Rubin, Axel Cederholm, Masato Ogishi, Carlos A. Arango-Franco, Vivien Béziat, Romain Lévy, Mélanie Migaud, Franck Rapaport, Yuval Itan, Elissa K. Deenick, Irene Cortese, Andrea Lisco, Kaan Boztug, Laurent Abel, Stéphanie Boisson-Dupuis, Bertrand Boisson, Patrick Frosk, Cindy S. Ma, Nils Landegren, Fatih Celmeli, Jean-Laurent Casanova, Stuart G. Tangye, Anne Puel
Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation
Journal of Infection· 2024DOI
Matthias Bruhn, Maureen Obara, Abhishek Chiyyeadu, Bibiana Costa, Abdus Salam, Annett Ziegler, Inken Waltl, Andreas Pavlou, Agnes Bonifacius, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Britta Eiz-Vesper, Axel Schambach, Ulrich Kalinke
Pharmaceuticals
Pharmaceuticals (Basel)· 2024DOI
Centofanti et al.
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency
Journal of Experimental Medicine· 2024DOI
Yi-Hao Chan, Vanja Lundberg, Jérémie Le Pen, Jiayi Yuan, Danyel Lee, Francesca Pinci, Stefano Volpi, Koji Nakajima, Vincent Bondet, Sanna Åkesson, Noopur V. Khobrekar, Aaron Bodansky, Likun Du, Tina Melander, Alice-Andrée Mariaggi, Yoann Seeleuthner, Tariq Shikh Saleh, Debanjana Chakravarty, Per Marits, Kerry Dobbs, Sofie Vonlanthen, Viktoria Hennings, Karolina Thörn, Darawan Rinchai, Lucy Bizien, Matthieu Chaldebas, Ali Sobh, Tayfun Özçelik, Sevgi Keles, Suzan A. AlKhater, Carolina Prando, Isabelle Meyts, null null, Paul Bastard, Alessandro Borghesi, Aziz Bousfiha, Oksana Boyarchuk, Petter Brodin, Jacinta Bustamante, Giorgio Casari, Rémi Chevalier, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Juan Carlos Aldave Becerra, Lisa Arkin, Evangelos Andreakos, Christian W. Thorball, Sara Espinosa, Carlos Flores, Amyrath Geraldo, Rabih Halwani, Nevin Hatipoğlu, Brahim Melaiki, Jacques Fellay, Alenka Gagro, Yuval Itan, Chandima Jeewandara, Filomeen Haerynck, Davood Mansouri, Leslie Naesens, Lisa F.P. Ng, Keisuke Okamoto, Pere Soler-Palacin, Laurent Renia, Aurora Pujol Onofre, Igor B. Resnick, José Luis Franco Restrepo, Jacques G. Rivière, Anna Scherbina, Anna Šedivá, Mikko R.J. Seppänen, Helen Su, Stuart G Tangye, Sehime G. Temel, Ahmad Abou Tayoun, Stuart Turvey, K.M. Furkan Uddin, Diederik van de Beek, Tom Le Voyer, Donald C. Vinh, Shen-Ying Zhang, Jean-Laurent Casanova, Michael R. Wilson, Jérémie Rosain, Emmanuelle Jouanguy, Mélodie Aubart, Laurent Abel, Trine H. Mogensen, Qiang Pan-Hammarström, Daxing Gao, Darragh Duffy, Aurélie Cobat, Stefan Berg, Luigi D. Notarangelo, Oliver Harschnitz, Charles M. Rice, Lorenz Studer, Jean-Laurent Casanova, Olov Ekwall, Shen-Ying Zhang
Smoking changes adaptive immunity with persistent effects
Nature· 2024DOI
Violaine Saint-André, Bruno Charbit, Anne Biton, Vincent Rouilly, Céline Possémé, Anthony Bertrand, Maxime Rotival, Jacob Bergstedt, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy, null null, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Christophe D’Enfert, Caroline Demangel, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Mickaël Ménager, Frédérique Michel, Hugo Mouquet, Cliona O’Farrelly, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer
The “Black Swan Principle” and the Genetics of Complex Diseases
Top Italian Scientists Journal· 2024DOI
Giuseppe Novelli, Juergen K V Reichardt
The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants
Science· 2024DOI
Marie Materna, Ottavia M. Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E. Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A. Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc’h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A. Schramm, Sanjana Shah, John J. Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S. Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P. Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R. Regueiro, Maria L. Toribio, Judith R. Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C. Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E. Henrickson, Hervé Luche, Luigi D. Notarangelo, Jean-Laurent Casanova, Vivien Béziat
The Microbe, the Infection Enigma, and the Host
Annual Review of Microbiology· 2024DOI
Jean-Laurent Casanova, Laurent Abel
The ouroboros of autoimmunity
Nature Immunology· 2024DOI
Jean-Laurent Casanova, Jessica Peel, Jean Donadieu, Anna-Lena Neehus, Anne Puel, Paul Bastard
Variation of the 3’RR1 HS1.2 Enhancer and Its Genomic Context
Genes· 2024DOI
Carla Jodice, Patrizia Malaspina, Bianca Maria Ciminelli, Cristina Martinez-Labarga, Michela Biancolella, Giuseppe Novelli, Andrea Novelletto
Viruses
Viruses· 2024DOI
Campos-Gonzalez et al.
Ancient DNA as a tool for medical research
Nature Medicine· 2023DOI
Kerner et al.
Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs
Frontiers in Immunology· 2023DOI
von Gunten et al.
Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia
Journal of Clinical Immunology· 2023DOI
Philippot et al.
COVID-19 annual update: a narrative review
Hum Genomics· 2023DOI
Biancolella et al.
COVID-19: S-Peptide RBD 484–508 Induces IFN-γ T-Cell Response in Naïve-to-Infection and Unvaccinated Subjects with Close Contact with SARS-CoV-2-Positive Patients
Viruses· 2023DOI
Murdocca et al.
Dissecting human population variation in single-cell responses to SARS-CoV-2
Nature· 2023DOI
Bisiaux et al.
Genome Medicine
Genome Medicine· 2023DOI
Matuozzo et al.
Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage
Cellular & Molecular Immunology· 2023DOI
Nehlmeier et al.
Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants.
Annual Review of Biomedical Data Science· 2023DOI
Cobat et al.
Human inherited complete STAT2 deficiency underlies inflammatory viral diseases
Journal of Clinical Investigation· 2023DOI
Bucciol et al.
Immune responses to SARS-CoV-2 infection and vaccination in children
Seminars in Immunology· 2023DOI
Brodin, Petter
Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children
Journal of Allergy and Clinical Immunology· 2023DOI
Bucciol et al.
Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia
Annual Review of Immunology· 2023DOI
Su et al.
International Journal of Molecular Sciences
International Journal of Molecular Sciences· 2023DOI
Arora et al.
Journal of Interferon and Cytokine Research
Journal of Interferon & Cytokine Research· 2023DOI
Vanker et al.
Nature Communications
Nature Communications· 2023DOI
Hoffmann et al.
Neutralisation sensitivity of SARS-CoV-2 lineages EG.5.1 and XBB.2.3
The Lancet Infectious Diseases· 2023DOI
Zhang et al.
Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage
The Lancet Infectious Diseases· 2023DOI
Arora et al.
PCSK3 Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-γ Gene Expression
Genes· 2023DOI
Latini et al.
Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein
JACS Au· 2023DOI
Budhadev et al.
Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5
Cellular & Molecular Immunology· 2023DOI
Hoffmann et al.
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Journal of Experimental Medicine· 2022DOI
Zhang et al.
From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
Cell· 2022DOI
Casanova & Abel
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
Journal of Experimental Medicine· 2022DOI
Sokal et al.
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Journal of Experimental Medicine· 2022DOI
Garcia-Carcia et al.
Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity
Journal of Allergy and Clinical Immunology· 2022DOI
Tangye et al.
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children
Science· 2022DOI
Lee et al.
Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α
Annals of the Rheumatic Diseases· 2022DOI
Mathian et al.
Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75
The Lancet Infectious Diseases· 2022DOI
Arora et al.
Omicron sublineage BQ.1.1 resistance to monoclonal antibodies
The Lancet Infectious Diseases· 2022DOI
Arora et al.
Pathogens
Pathogens· 2022DOI
Skouboe et al.
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Journal of Experimental Medicine· 2022DOI
Zhang et al.
The genetic and evolutionary determinants of COVID-19 susceptibility
European Journal of Human Genetics· 2022DOI
Kerner et al.
Deliverables (12)
Other Results (1)
Periodic Reporting for period 2 - UNDINE (The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine)