Bimetallic Complexes for the Activation and Catalytic Functionalisation of Vinylic C-H Bonds

The catalytic and selective functionalisation of C–H bonds of organic molecules is a key enabling technology that has the potential to contribute to the sustainable production of commodity chemicals. This proposal targets the selective catalytic functionalisation of vinylic C–H bonds of unactivated olefins (e.g. ethylene, propylene) with novel heterometallic complexes based on abundant and inexpensive elements (e.g. Fe, Al or Ga). Despite appearing simple, this transformation is unprecedented. With nearly all systems studied to date, competitive π-coordination of the olefin to the metal site inhibits catalytic C–H functionalisation. In this project, the cooperativity between two adjacent metals will be used to create new mechanistic pathways that circumvent this issue. The proposal is divided into three distinct work packages focussing on (i) the development of new heterometallic complexes, (ii) their application in stoichiometric vinylic C–H activation and (iii) establishment of catalytic turnover for C–H functionalisation of unactivated olefins. Ultimately the new understanding and new methodology will be applied to the production of vinyl-alkoxysilanes, high-demand and industrial relevant polymer building blocks, from C–H functionalisation of ethylene. Successful realisation of this proposal will provide the fellow with additional know-how in bimetallic chemistry, C–H activation, and catalysis, expanding his skill set beyond his expertise in organometallic and main group chemistry. Additional experience and training in aspects of leadership, teaching and management will complement the fellow’s education to a degree of professional maturity, making him highly competitive for independent funding and positions in academia.